Pharmaceutical

Particle Technology Labs is recognized by the United States pharmaceutical industry as an expert in the field of particle characterization. Not only are thousands of individual analyses performed at Particle Technology Labs each year, but many particle characterization methods and techniques are developed and validated as well for our clients in the pharmaceutical industry.

Pharmaceutical companies rely on particle characterization testing for a wide variety of applications from development of active ingredients to problem-solving in manufacturing

Applications

Drug Formulation — the careful blending and processing of precisely specified and measured components to create a final drug product that delivers the desired clinical dose is a process known as formulation. The information provided by the services offered at Particle Technology Labs such as particle size distribution, shape, porosity, and more can prove invaluable to pharmaceutical drug formulation.

Drug Behavior and Performance — particle size distribution can affect performance of pharmaceutical drugs significantly. The stability, aesthetics, rate of absorption, and bioavailability are all affected by the size of the particles that comprise a powder or dispersion. Regulatory agencies are aware of the importance of particle size, requiring drug developers to maintain greater control and understanding of the physical characteristics of their products.

Particle Shape — particle shape can be measured to increase the understanding and control of the manufacturing process. While two particles may be the same size, their shape may differ impacting behavior and performance. Understanding particle shape can help detect problems during powder flow or particle abrasion. Characterization results can lead to better development of pharmaceutical drugs.

Surface Area and Porosity – important factors in the purification, processing, tableting, and packaging of pharmaceutical products as well as a drug’s useful shelf-life, dissolution rate, and bioavailability can all be affected by the surface area and porosity of the components used in manufacturing. The services offered by the experts at Particle Technology Labs can lead to a better understanding of these factors.