PTL Articles

Surface Area Sample Preparation - Eric Olson

Specific surface area is a fundamental measurement in the field of fine particle characterization. Specific surface area measurements have numerous pharmaceutical manufacturing and quality applications. Click for Article

Micron-ranged Particle Sizing Techniques - Amy Sabin

Given the wide range of particle sizing technologies and instrumentation on the market, the choice of measurement technique can be daunting, especially if one is unfamiliar with the options available. Click for Article

Specifics on Surface Area - Rebecca Wolfrom

Surface area is an important property of solids with many industrial applications. Particle size is less influential on surface area than particle shape, texture, and porosity. Surface area calculated from particle size data should never be used independently. Click for Article

Zeta Potential and Colloid Chemistry - Eric Olson

This discussion outlines current guidance to aid quality units with potential issues and questions; reviews the complex topics of colloid chemistry and zeta potential; and provides insight to chemists who may require zeta potential determination, but who may not be well versed in these topics. Click for Article

 Particle Dispersion for Size Analysis - Jorie Kassel

  Particle size analysis is a vital analytical tool in the pharmaceutical industry. The results can be used to meet safety and quality specifications and provide information for product development and manufacturing. Modern techniques have made determining the particle size of a material quick and convenient, but many factors can influence the quality of data obtained. Click for Article

Problems in Particle Size: Laser Diffraction - Amy Sabin

  The results obtained by a particle size analysis can easily be taken for granted. If the particle size distribution of a material must be quantified and reported, it is important that the full implications of the analytical technique and generated data are investigated and understood. Click for Article

Particle Shape Factors & Their Use in Image Analysis Part I - Eric Olson

  Fine particle characterization is most effective when accomplished through a methodical process. The first step of this process often involves determining what material needs characterization. Click for Article

Particle Shape Factors & Their Use in Image Analysis Part 2: Practical Applications - Eric Olson

  Shape plays an important role in fine particles in many ways. For instance, the correlation between specific surface area and pharmaceutical dissolution is well documented and governed by Fick’s first law of diffusion. Click for Article

The Language of Particle Size - Rebecca Wolfrom

  Most practitioners in the pharmaceutical, mining, environmental, paints and coatings, and other fields have reason to know the sizes of particles in a given powder or slurry sample. While many technologies exist to describe that collection of sizes, the reports delivered by those technologies are written in their own vocabulary. Click for Article

Blending of Log Normal Particle Size Data from Multiple Analyses into Continuous Data Set - Eric Olson

There are many methods of measuring particle size, one of which is by image analysis. The process of particle size measurement by image analysis is very well established and accepted, as proven by the number of International Organization for Standardization (ISO), ASTM, and other standards on this methodology. Click for Article